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The chondroprotection efficacy of copper may be attributable to the anti-catabolic effects of Cu 2+ , which abrogates the degradation of cartilage matrix proteoglycan via inhibition of nitric oxide release (Pasqualicchio et al., 1996)

Ortega MA, Fraile-Martinez O, Garca-Montero C, Callejn-Pelez E, Sez MA, lvarez-Mon MA

It accelerates wound healing by improving blood flow and increasing collagen production but also promotes healing of all body tissues including the heart and brain

Understanding these metabolic interactions is essential, as targeting a single pathway such as glycolysis may cause compensatory shifts in another (FAO), so successful therapies might need to address the metabolic network as a whole

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In contrast to these ineffective and nonspecific therapies, another therapeutic approach involving glutathione esters appears more specific and more promising